Publications
Peer-reviewed research articles, reviews and commentaries, and a manuscript under review.
Entries are based on the supplied publication list. DOI links appear where confirmed; remaining bibliographic links require verification before launch.
Research articles 10
Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB): A Translational Pharmacodynamic Biomarker for PIKfyve Inhibition with VRG50635
Gontier G.**, Kim G.**, Wang C., Zhu K., Gau R., Zhang N., Naphade S., Stewart A., Schmidt M.J., Galemmo R., Shook B., Tarachandani A., Choi I., Raines S., Scannevin R.H., Grievink H.W., Smits L.M.G., Kremer P.H.C., Cadavid D. (2026). Clinical and Translational Science.
** Co-first authors.
DOI ↗Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function
Pratt K.J.B., Shea J.M., Remesal-Gomez L., Bieri G., Smith L.K., Couthouis J., Chen C.P., Roy I.J., Gontier G.*, Villeda S.A.* (2022). Cell Reports.
* Co-last authors.
MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling
Lin K., Bieri G., Gontier G., Müller S., Smith L.K., Snethlage C.E., White C.W., Maybury-Lewis S.Y., Villeda S.A. (2021). PLOS Biology.
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain
Horowitz A.M., Fan X., Bieri G., Smith L.K., Sanchez-Diaz C., Schroer A.B., Gontier G., et al. (2020). Science.
DOI ↗Tet2 rescues age-related regenerative decline and enhances cognitive function in adult mouse brain
Gontier G., Iyer M., Shea J.M., Bieri G., et al. (2018). Cell Reports.
DOI ↗The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons
George C., Gontier G., Lacube P., et al. (2017). Brain.
Blocking IGF signaling in adult neurons alleviates Alzheimer's disease pathology through amyloid-β clearance
Gontier G., George C., Chaker Z., et al. (2015). Journal of Neuroscience.
DOI ↗β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Smith L.K., He Y.B., Park J.S., et al. (2015). Nature Medicine.
DOI ↗Longevity effect of IGF-1R+/- mutation depends on genetic background-specific receptor activation
Gontier G., Xu J., Chaker Z., et al. (2014). Aging Cell.
Elevated production of reactive oxygen species by polymorphonuclear neutrophils in cerebrospinal fluid infection
Gontier G., Lukaszewicz A.C., Faivre V., et al. (2012). Annals of Intensive Care.
Reviews & commentaries 2
Fat Chance for Neural Stem Cells in Alzheimer’s Disease
Gontier G., Lin K., Villeda S.A. (2015). Cell Stem Cell.
Commentary.
IGF and insulin signaling pathways in longevity
Gontier G., Holzenberger M. (2010). Biologie Aujourd’hui.
Review; French.
Manuscripts under review 1
This manuscript has not been published. The status and public-disclosure permissions should be reconfirmed before launch.
Inhibition of CD38 with VRG201 rescues multiple pathophysiological features of obesity and metabolic disorders in preclinical models
Zhang N.*, Blockus H.*, Gontier G., Madero-Perez J., Ayhan F., Wong N., Viera Ortiz A., Gau R., Wang C., Heinrich L., Dhara M., Modan S., Taylor P., Andreoletti G., Shah K., Dulcey A., Shook B., Frank C., Choi I., Scannevin R.H. Manuscript under review.
* Equal contributions indicated in supplied citation; verification pending.